{"id":22513,"date":"2022-04-04T23:50:33","date_gmt":"2022-04-04T23:50:33","guid":{"rendered":"https:\/\/pr.asianetpakistan.com\/?p=89438"},"modified":"2022-04-04T23:50:33","modified_gmt":"2022-04-04T23:50:33","slug":"bright-peak-therapeutics-announces-multiple-presentations-at-the-american-association-for-cancer-research-aacr-annual-meeting","status":"publish","type":"post","link":"https:\/\/myanmarnewswire.com\/bright-peak-therapeutics-announces-multiple-presentations-at-the-american-association-for-cancer-research-aacr-annual-meeting\/","title":{"rendered":"Bright Peak Therapeutics Announces Multiple Presentations at the American Association for Cancer Research (AACR) Annual Meeting"},"content":{"rendered":"
–Oral Presentation to highlight the creation of next-generation biologics using a novel chemistry platform technology\u2014<\/em><\/p>\n –Poster presentation describing the cis-activation of PD-1+ effector T cells with dual-targeting immunocytokines generated using a novel chemical conjugation platform\u2014<\/em><\/p>\n –Poster presentation to demonstrate the power of our novel chemical protein synthesis technology by engineering a pleiotropic native cytokine into an optimized cancer therapeutic\u2014<\/em><\/p>\n SAN DIEGO and BASEL, Switzerland, April 04, 2022 (GLOBE NEWSWIRE) — Bright Peak Therapeutics, a biotechnology company developing next-generation cytokine immunotherapies to treat cancer and autoimmune disease, today announced the acceptance of one oral presentation and two poster presentations at the American Association for Cancer Research (AACR) Annual Meeting taking place April 8-13, 2022, in New Orleans, Louisiana.<\/p>\n \u201cWe\u2019re thrilled to present details on the broad applications of Bright Peak\u2019s innovative chemical protein synthesis and conjugation technology at AACR 2022,\u201d said Fredrik Wiklund, President and CEO. \u201cThis is the first time we are showcasing our novel platform at such an important scientific meeting, and we look forward to contributing to the advancement of immunomodulatory cancer agents and interventions through our highly differentiated approach.\u201d<\/p>\n Details of the abstracts and presentations are as follows:<\/p>\n Oral Presentation:\u00a0 Creating next-generation biologics using a novel chemistry platform technology<\/strong> Title:\u00a0 Cis-activation of PD-1+ effector T cells with dual-targeting immunocytokines generated using a novel chemical conjugation platform<\/strong> Abstract Highlights: <\/strong>Bright Peak has developed a cell-free chemical protein synthesis and conjugation platform to rapidly generate optimized antibody-cytokine (immunocytokine) therapeutics within weeks. The Bright Peak immunocytokine platform features flexible “plug and play” technology whereby our enhanced cytokine payloads are chemically conjugated to existing antibodies obtained “off the shelf”. Bright Peak generates enhanced and conjugatable cytokine payloads using a novel protein engineering platform based on solid-phase peptide synthesis and subsequent chemical ligation of protein segments and protein folding. Our cytokine payloads are designed with optimized properties and conjugation handles during chemical synthesis and are then readily chemically conjugated to specific lysine residues in the Fc region of an existing IgG1, IgG2 or IgG4 antibody without the need for prior antibody engineering.<\/p>\n We are initially focusing on the development of PD-1-targeted immunocytokines (ICs) that dual-target PD-1+ effector T cells (cis<\/em>-signaling) to achieve potent and selective activation of tumor antigen-experienced effector T cells. Resulting PD-1\/IL-2 ICs are highly active showing significantly enhanced potency due to avidity resulting from binding of the cytokine payload to PD-1+ effector T cells in cis<\/em>. Our PD-1\/IL-2 ICs induce strong pharmacodynamic effects in vivo<\/em>, and we are currently optimizing the pharmacological profiles of PD-1-targeted immunocytokines for clinical application.<\/p>\n Title:\u00a0 BPT-143: A fully synthetic alpha-dead IL-2 with a best-in-class preclinical pharmacodynamic and efficacy profile supporting first-in-human clinical development<\/strong> Abstract Highlights: <\/strong>As a proof of concept for our chemical protein synthesis platform, we set out to engineer a variant of human IL-2 that solves the major limitations of immuno-oncology therapeutics based on wildtype IL-2 (e.g, aldesleukin). Using our chemical protein synthesis technology, we rationally designed an enhanced cytokine payload with select modified amino acids to introduce site-specific chemical conjugation handles and specific sequence variations to optimize the biological properties of IL-2 for cancer therapy while maintaining high homology to the wildtype IL-2 sequence. Bright Peak\u2019s enhanced cytokine payload is engineered for increased binding to CD122\/IL2R\u03b2 and does not interact with CD25\/IL2R\u03b1 to improve safety and prevent the preferential activation of Tregs compared to CD8+ T effector cells. The fully synthetic cytokine payload can then be conjugated to a 30 kDa PEG for optimal pharmacokinetic properties or to a monoclonal antibody to create a novel Bright Peak immunocytokine.<\/p>\n We successfully manufactured our full-length, folded and PEGylated protein (BPT-143) under GMP conditions to amounts sufficient for clinical development. BPT-143 demonstrates the power of our synthetic protein synthesis platform to engineer pleiotropic native cytokines into optimized therapeutics and are exploiting our technology to develop a pipeline of novel designer cytokines and multi-modal immune therapies.<\/p>\n The abstracts can be accessed through the AACR meeting planner and are available for viewing online here:<\/p>\n https:\/\/www.abstractsonline. https:\/\/www.abstractsonline.
\nMinisymposium MS.CH01.01:<\/u>\u00a0Drug Design and Lead Optimization Strategies Toward Novel or Difficult-to-Drug Cancer Targets
\nDate and Time:<\/u>\u00a0April 11, 2022, 3:50 \u2013 4:05 PM\u00a0(CDT)<\/p>\n
\nSession Title:<\/u>\u00a0Immunomodulatory Agents and Interventions 3
\nDate and Time:<\/u>\u00a0 April 13, 2022, 9:00 AM – 12:30 PM\u00a0(CDT)
\nAbstract Number:<\/u>\u00a04223, Section 38<\/p>\n
\nSession Title:<\/u>\u00a0Immunomodulatory Agents and Interventions 3
\nDate and Time:<\/u>\u00a0 April 13, 2022, 9:00 AM – 12:30 PM\u00a0(CDT)
\nAbstract Number:<\/u>\u00a04224, Section 38<\/p>\n